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2025 Prohibited List

The new list came into force on 1 January 2025.

The 2025 Prohibited List came into force on 1 January 2025.

 

The World Anti-Doping Agency (WADA) has published the:

 

An update on changes to the List is included in Sport Integrity Australia’s 2025 Annual Update course for athletes and support personnel.

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Major modifications for 2025

Substances and methods prohibited at all times (In- and Out-of-Competition)

S0. Non-Approved Substances

  • S-107 and S48168 (ARM210) were added to S0 as examples of the class of ryanodine receptor-1- calstabin complex stabilizers. The ryanodine receptor-1-calstabin complex is a major component of calcium storage and release, serving to maintain skeletal muscle function.

S3. Beta-2 Agonists

  • Based on a recent publication on potential performance-enhancing doses of inhaled formoterol, the dosing intervals were updated to ensure that ergogenic effects are not achieved. These new 12-hourly dosing intervals are consistent with manufacturers’ recommended use; the maximum delivered dose is unchanged at 54 micrograms over 24 hours

S4. Hormone and Metabolic Modulators

  • Elacestrant was added as an example of an anti-estrogen. 
  • Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) was added as an example of an AMP-activated protein kinase activator. 
  • For clarity, S519 and S597 were added as examples of insulin-mimetics. Insulin-mimetics compounds or selective insulin receptor modulators (SIRMs) mimic insulin action by binding to the insulin receptor.

S5. Diuretics and Masking Agents

  • Xipamide was added as an example of a diuretic.

M1. Manipulation of Blood and Blood Components

  • Donation of blood or blood components (e.g. plasma, red blood cells, white blood cells, platelets and peripheral blood stem cells) including by apheresis is not prohibited when performed in a collection centre accredited by the relevant regulatory authority of the country in which it operates.

M3. Gene and Cell Doping

  • Minor editorial change was made for clarity.

Substances and methods prohibited in-competition

S6. Stimulants

  • Hydrafinil (fluorenol) was changed from S6.B to S6.A, as this substance is more potent than modafinil and is not licensed for medical use. 
  • Midodrine and Tesofensine were added as examples of specified stimulants. 
  • Guanfacine was clarified as not prohibited.

Prohibited in particular sports

P1. Beta-Blockers

  • Based on information provided by International Ski and Snowboard Federation (FIS), the skiing/snowboarding disciplines of ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air were removed.

Monitoring Program

  • Fentanyl and tramadol were added to monitor patterns of Out-of-Competition use.