Higenamine is classified as an S3 Beta-2 Agonist (these types of substances allow lungs to take in more oxygen) and is prohibited in and out-of-competition. However, as a cardiotonic, higenamine can increase heart rate, putting an athlete at an increased risk of arrhythmias and even death.
Despite being marketed as “natural”, Higenamine is one of the leading causes of positive doping tests in Australia.